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KMID : 0370219960400020230
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Yakhak Hoeji
1996 Volume.40 No. 2 p.230 ~ p.237
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Effects of Epimedii Herba Fraction on Response in ICR Mice
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김정훈/Kim JH
김인훈/채병숙/강태욱/박찬봉/안영근/Kim IH/Chae BS/Kang TW/Park CB/Ahn YK
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Abstract
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The fractions of Epimedii Herba were examined for the immunological effects in ICR mice. Mice were divided into 4 groups and administered orally the fractions of Epimedii Herba for 10 days. The results of this study were summarized as following: (1) The fraction 1 (EtOAc layer) administered group as compared with control group significantly decreased spleen weight, Arthus reaction and hemagglutination (HA) titer but significantly increased circulating white blood cells (WBC). (2) The fraction 2 (H20 layer) administered group as compared with control group significantly decreased liver weight, Arthus reaction and HA titer but significantly increased WBC. (3) The fraction 3 (ppt) administered group as compared with control group significantly increased liver weight, thymus weight rate, delayed type hypersensitivity, phagocytic activity and WBC. The results showed that Frs. 1 and 2 administered groups reduced humoral immune response but increased WBC, and that Fr. 3 administered group increased cell-mediated immune response, phagocytic activity and WBC.
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KEYWORD
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